The brain mechanisms for learned safety

习得性安全的大脑机制

• 批准号: nhmrc : GNT1138069
• 负责人: Dr John Power
• 金额: $ 55.94万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/brain-mechanisms-learned-safety/1348115
• 关键词: brain; mechanisms; learned; safety

A core feature of clinical anxiety is the inability to learn about safety and suppress fear. Impaired safety learning underpins excessive fear responding, overgeneralisation of fear, as well as treatment resistance in clinical anxiety. Very little is known about the brain mechanisms for learned safety. This project maps and manipulates these mechanisms to lay the basic science foundation for the next generation of treatments of anxiety.

临床焦虑的一个核心特征是无法了解安全性并抑制恐惧。安全学习受损会导致过度恐惧反应、恐惧过度概括以及临床焦虑症的治疗抵抗。人们对习得性安全的大脑机制知之甚少。该项目绘制并操纵这些机制，为下一代焦虑治疗奠定基础科学基础。