Breast Cancer Risk after Diagnostic Gene Sequencing (BRIDGES)

诊断基因测序后的乳腺癌风险 (BRIDGES)

• 批准号: nhmrc : GNT1101400
• 负责人: Prof Amanda Spurdle
• 金额: $ 47.13万
• 依托单位国家: 澳大利亚
• 项目类别: International Collaborations
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/breast-cancer-risk-sequencing-bridges/1346159
• 关键词: Breast; Cancer; Risk; after; Diagnostic

In BRIDGES, we aim to build a knowledge base to better define individual breast cancer risk. We bring together, in a multidisciplinary team, data and expertise from clinical genetics, epidemiology, bioinformatics, statistics, and gene biology. Specifically, we will use state-of-the art DNA screening to evaluate all suspected breast cancer genes in a large sample of breast cancer cases and controls. We will then use in silico and in vitro functional analyses to evaluate the likely pathogenicity o

在BRIDGES项目中，我们的目标是建立一个知识库，以更好地定义个体乳腺癌风险。我们汇集了来自临床遗传学、流行病学、生物信息学、统计学和基因生物学的多学科团队的数据和专业知识。具体来说，我们将使用最先进的DNA筛查来评估大量乳腺癌病例和对照样本中所有可疑的乳腺癌基因。然后，我们将使用计算机和体外功能分析来评估o的可能致病性