BRIDGET: BRain imaging, cognition, Dementia and next generation GEnomics: a Transdisciplinary approach to search for risk and protective factors of neurodegenerative disease

布里奇特：脑成像、认知、痴呆和下一代基因组学：寻找神经退行性疾病风险和保护因素的跨学科方法

• 批准号: nhmrc : GNT1115462
• 负责人: A/Pr Wei Wen
• 金额: $ 108.15万
• 依托单位国家: 澳大利亚
• 项目类别: Boosting Dementia Research Initiative
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/bridget-brain-imaging-neurodegenerative-disease/1346954
• 关键词: BRIDGET; BRain; imaging; cognition; Dementia

Alzheimer’s disease (AD) begins many years before diagnosis and yet its aetiology is still poorly understood. The BRIDGET consortium aims to identify genetic variants that are associated with structural brain ageing, cognitive performance, and dementia risk in richly phenotyped international and Australian population-based samples. This work aims to provide crucial information on the molecular pathways leading to AD, potentially leading to improved health outcomes for our ageing population.

阿尔茨海默病（AD）在诊断前许多年就开始了，但其病因仍然知之甚少。BRIDGET联盟的目标是在丰富的表型国际和澳大利亚人群样本中识别与结构性脑老化，认知能力和痴呆风险相关的遗传变异。这项工作旨在提供有关导致AD的分子途径的关键信息，可能会改善我们老龄化人口的健康状况。