The genetic and environmental determinants of amyloid deposition in older individuals: an amyloid imaging study using the twin design

老年人淀粉样蛋白沉积的遗传和环境决定因素：使用双胞胎设计的淀粉样蛋白成像研究

• 批准号: nhmrc : GNT1085606
• 负责人: A/Pr Wei Wen
• 金额: $ 62.54万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genetic-environmental-determinants-twin-design/1345633
• 关键词: genetic; environmental; determinants; amyloid; deposition

Alzheimer’s disease is characterised by the deposition of amyloid plaques in the brain. We don’t fully understand how amyloid deposition occurs and what contribution is made by genetic and environmental factors. Amyloid deposition in the brain can now be quantified during life using positron emission tomography. In this study, we will examine brain amyloid in twins, which will determine what proportion of the pathology is attributable to environmental factors that may be modifiable.

阿尔茨海默病的特点是大脑中淀粉样斑块的沉积。我们并不完全了解淀粉样蛋白沉积是如何发生的，以及遗传和环境因素对淀粉样蛋白沉积的影响。大脑中的淀粉样蛋白沉积现在可以通过使用正电子发射断层扫描来量化。在这项研究中，我们将检查双胞胎的脑淀粉样蛋白，这将确定可归因于可改变的环境因素的病理比例。