Bridging the GAPP between the laboratory and clinic to prevent Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS).

在实验室和诊所之间架起 GAPP 的桥梁，预防胃腺癌和胃近端息肉病 (GAPPS)。

• 批准号: nhmrc : GNT1143414
• 负责人: A/Pr Daniel Worthley
• 金额: $ 72.49万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/bridging-gapp-laboratory-stomach-gapps/1348530
• 关键词: Bridging; GAPP; between; laboratory; clinic

Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS) is an inherited form of gastric cancer. Affected patients develop a large number of gastric polyps and are at risk of gastric cancer in their 30s. The only effective treatment is to surgically remove the stomach. Gastrectomy is, however, associated with significant post-operative complications. We will use laboratory and mouse models of GAPPS to identify acceptable new approaches to prevent cancer in these patients.

胃腺癌和胃近端息肉病(GAPPS)是一种遗传性胃癌。受影响的患者在30多岁时会出现大量胃息肉，并有患胃癌的风险。唯一有效的治疗方法是手术切除胃。然而，胃切除术与严重的术后并发症有关。我们将使用实验室和小鼠模型的GAPPS来确定可接受的新方法来预防这些患者的癌症。