Osteochondroreticular stem cell therapy for osteoarthritis: the right cells for the job.

骨软骨网状干细胞治疗骨关节炎：适合这项工作的细胞。

• 批准号: nhmrc : GNT1099283
• 负责人: A/Pr Daniel Worthley
• 金额: $ 56.2万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/osteochondroreticular-stem-cell-cells-job/1346048
• 关键词: Osteochondroreticular; stem; cell; therapy; osteoarthritis

'Wear and tear' arthritis of the knee, hip and back joints is known as osteoarthritis. This causes significant health burden and costs in our community, particularly in older Australians. Osteoarthritis begins with the loss of joint cartilage. We believe that a new type of stem cells (OCR stem cells) offer the greatest promise to generate and thus therapeutically replace joint cartilage. Our studies test this hypothesis and develop preclinical translation of our discoveries in mice into humans.

膝盖、臀部和背部关节的“磨损性”关节炎被称为骨关节炎。这给我们的社区，特别是澳大利亚老年人造成了巨大的健康负担和费用。骨关节炎始于关节软骨的丧失。我们相信，一种新型干细胞（OCR干细胞）提供了最大的希望，以产生并因此治疗替代关节软骨。我们的研究验证了这一假设，并将我们在小鼠身上的发现转化为人类的临床前研究。