Defining the role of reserve stem cells in gastric cancer

定义储备干细胞在胃癌中的作用

• 批准号: nhmrc : 1120362
• 负责人: A/Pr Daniel Worthley
• 金额: $ 38.47万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-role-reserve-gastric-cancer/946513
• 关键词: Defining; role; reserve; stem; cells

Over 800,000 deaths from stomach cancer occur annually. This often fatal disease is caused by chronic inflammation of the stomach lining. This proposal will investigate how stomach inflammation ‘reprograms’ a new type of 'cancer stem cell' to form tumours and evaluate ways to therapeutically target these cells to prevent disease. Collectively, these studies will inform new approaches for stomach cancer prevention and treatment.

每年有超过80万人死于胃癌。这种通常致命的疾病是由胃粘膜的慢性炎症引起的。该提案将研究胃部炎症如何“重新编程”一种新型的“癌症干细胞”以形成肿瘤，并评估治疗靶向这些细胞以预防疾病的方法。总的来说，这些研究将为胃癌预防和治疗提供新的方法。