Cell Surface Mucins in Gastrointestinal Infection, Inflammation and Cancer Development

细胞表面粘蛋白在胃肠道感染、炎症和癌症发展中的作用

• 批准号: nhmrc : 1060698
• 负责人: Dr Yong Sheng
• 金额: $ 31.31万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cell-surface-mucins-cancer-development/454848
• 关键词: Cell; Surface; Mucins; Gastrointestinal; Infection

Cell surface mucins are protective molecules that line all the wet surface of the body, including the gastrointestinal tract. Our research has uncovered that mucins regulate cell growth and cell death. Inappropriate control by the mucins, could lead to chronic inflammation and formation of cancers. We will test how important these molecules are in the development of cancers in the intestine, and further explore the mechanism of action.

细胞表面粘蛋白是保护性分子，排列在身体的所有潮湿表面，包括胃肠道。我们的研究发现，粘蛋白调节细胞生长和细胞死亡。粘蛋白的不当控制，可能导致慢性炎症和癌症的形成。我们将测试这些分子在肠道癌症发展中的重要性，并进一步探索其作用机制。