Cellular metabolism and signalling in cardiac development and congenital disease

心脏发育和先天性疾病中的细胞代谢和信号传导

• 批准号: nhmrc : 1016543
• 负责人: Dr Freya Sheeran
• 金额: $ 10.07万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cellular-metabolism-signalling-congenital-disease/109786
• 关键词: Cellular; metabolism; signalling; cardiac; development

This project aims to investigate how the paediatric heart responds to oxidative cellular stresses during cardiac development, surgical stress and congenital heart disease. Pre-surgical interventions aims at improving cardiac function following surgery will be examined, with cellular models being used to determine molecular pathways of cardioprotection, as well as testing agents which may limit cellular damage under surgical stress and disease.

本项目旨在研究儿童心脏在心脏发育、手术应激和先天性心脏病期间如何对氧化细胞应激作出反应。旨在改善手术后心脏功能的术前干预措施将被检查，细胞模型将被用来确定心脏保护的分子途径，以及可能限制手术应激和疾病下细胞损伤的测试剂。