Centre for REdefining antibiotic use to reDUce resistanCE and prolong the lives of antibiotics (REDUCE)

重新定义抗生素使用以减少耐药性并延长抗生素寿命中心 (REDUCE)

• 批准号: nhmrc : GNT1099452
• 负责人: A/Pr Jan De Waele
• 金额: $ 215.83万
• 依托单位国家: 澳大利亚
• 项目类别: Centres of Research Excellence
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/centre-redefining-antibiotic-antibiotics-reduce/1346062
• 关键词: Centre; REdefining; antibiotic; use; reDUce

Ineffective dosing of antimicrobials has contributed to the escalation of antimicrobial resistance which now pervades the healthcare system. Patients in the intensive care unit and post-transplant are examples of patients who commonly have infections, are more likely to fail treatment and have resistant microbes emerge. In these studies we will characterise the doses of antimicrobials that should be used in these difficult-to-treat patients and rapidly share these for routine clinical use.

抗生素的无效剂量导致了抗生素耐药性的升级，这种耐药性现在遍布医疗保健系统。重症监护室和移植后的患者是通常患有感染的患者的例子，更有可能治疗失败并出现耐药微生物。在这些研究中，我们将确定这些难治性患者应使用的抗菌药物剂量，并迅速将其用于常规临床使用。