Centre of Research Excellence in Pulmonary and Environmental Medicine.

肺与环境医学卓越研究中心。

• 批准号: nhmrc : 458543
• 负责人: A/Pr Steven Mutsaers
• 金额: $ 133.84万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Centres of Research Excellence
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/centre-research-excellence-environmental-medicine/81715
• 关键词: Centre; Research; Excellence; Pulmonary; Environmental

This Centre will study inhalational lung diseases, ie diseases caused by substances such as asbestos, cigarette smoke, air pollutants and allergens. Australia has of the highest incidences in the world of at least 2 of the diseases to be studied, asbestos- and allergen-induced lung diseases. These two alone are estimated to cost the Australian economy over $100 million -yr and $1 billion respectively in direct health costs plus loss of productivity and compensation. Furthermore COPD on of our other major areas of interest is the 4th leading cause of death in males and conservatively costs the economy over one billion dollars per year as well as being the leading cause of disability in the elderly. It is predicted that COPD will be the 4th most common disease worldwide by 2020. As such this area of study is important for Australia and internationally and any advances will deliver major economic and health benefits. We will study the role of blood and sputum tests in the diagnosis, monitoring, screening and management of lung diseases caused by asbestos, cigarette smoke, air pollutants and allergens ie. mesothelioma, asthma, COPD and lung cancer. We will apply modern DNA 'gene chip' methods to study the pathogenesis of these diseases and help us to identify new treatment targets. This will also be used to guide genetic searches for polymorphism's, spliced variants and DNA modification(epigentics) in COPD and lung cancer. Genetic studies of sensitivity to air pollution will be used to define at risk patients We will also evaluate how the method of cell death that occurs during some therapies eg. in cancer and allergy-asthma, might alter how the body responds and thus help us develop novel therapeutic strategies for these diseases. This research program should lead to new tests and treatments and at the same time promote the training of a new generation of young researchers in this field and so ensure that the work continues long term

该中心将研究吸入性肺部疾病，即由石棉、香烟烟雾、空气污染物和过敏原等物质引起的疾病。澳大利亚是世界上发病率最高的至少两种待研究疾病，即由石棉和过敏原引起的肺部疾病。据估计，仅这两项就给澳大利亚经济造成了每年超过1亿美元和10亿美元的直接医疗成本，外加生产力损失和补偿。此外，在我们感兴趣的其他主要领域中，慢性阻塞性肺病是导致男性死亡的第四大原因，每年保守地造成超过10亿美元的经济损失，也是导致老年人残疾的主要原因。据预测，到2020年，COPD将成为全球第四大常见病。因此，这一研究领域对澳大利亚和国际都很重要，任何进展都将带来重大的经济和健康利益。我们将研究血液和痰检查在诊断、监测、筛查和治疗由石棉、香烟烟雾、空气污染物和过敏原引起的肺部疾病方面的作用。间皮瘤、哮喘、慢性阻塞性肺病和肺癌。我们将应用现代DNA‘基因芯片’方法来研究这些疾病的发病机制，并帮助我们确定新的治疗靶点。这也将被用于指导COPD和肺癌的多态、剪接变异和DNA修饰(表观遗传学)的遗传搜索。对空气污染敏感性的基因研究将被用来定义高危患者，我们还将评估在一些治疗中发生的细胞死亡的方法，例如。在癌症和过敏性哮喘中，它可能会改变身体的反应方式，从而帮助我们为这些疾病开发新的治疗策略。这项研究计划应该带来新的测试和治疗方法，同时促进这一领域新一代年轻研究人员的培训，从而确保这项工作长期持续下去