The role of the Hedgehog signaling pathway in asbestos associated malignant mesothelioma

Hedgehog信号通路在石棉相关恶性间皮瘤中的作用

• 批准号: nhmrc : 572676
• 负责人: A/Pr Steven Mutsaers
• 金额: $ 37.58万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-hedgehog-signaling-malignant-mesothelioma/83112
• 关键词: role; Hedgehog; signaling; pathway; asbestos

Mesothelioma is a aggressive asbestos related cancer mainly of the lung with no effective treatment. Evidence is pointing to the reactivation and aberrant expression of developmental signalling pathways such as the hedgehog signalling pathway as critical to the pathogenesis of certain types of cancer. This study will determine if mesothelioma is regulated by signalling through the hedgehog pathway and by blocking this pathway we will attempt to inhibit tumour growth.

间皮瘤是一种侵略性石棉相关的癌症，主要是肺部没有有效的治疗。有证据表明，发育信号通路（如刺猬信号通路）的重新激活和异常表达对某些类型癌症的发病机制至关重要。这项研究将确定间皮瘤是否受刺猬信号通路的调节，并通过阻断这一通路，我们将试图抑制肿瘤生长。