Synthetic inorganic and bioinorganic chemistry

合成无机和生物无机化学

• 批准号: 327649-2006
• 负责人: Lee, Sonny
• 金额: $ 3.06万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2006
• 资助国家: 加拿大
• 起止时间: 2006-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=335937
• 关键词: Synthetic; inorganic; bioinorganic; chemistry

The bacterial conversion of atmospheric nitrogen to ammonia is critical in making nitrogen chemically available to life on Earth.  It is a reaction of truly global significance.  The microbes use the nitrogenase enzyme to carry out this chemistry.  An unusual cluster of iron, sulfur, molybdenum, and nitrogen atoms is the site of reactivity within the enzyme.  How the cluster works is a mystery. We propose a research program that investigates some of this mystery.  Computer models suggest that interactions between iron and nitrogen atoms are at the heart of nitrogenase activity; such chemistry, however, has little precedent.  We want to develop and study these interactions in controlled synthetic systems in order to learn their fundamental properties.  We can then apply this basic knowledge towards analyzing and understanding the biological process. In the near-term, the results from our program will advance our understanding of fundamental inorganic and biological chemistry.  From a longer perspective, insights from this research have the potential to improve the efficiency and capabilities of economically-significant industrial chemical processes.  Students trained in this field will acquire a broad scientific research background with experience in a range of chemical and physical techniques; these qualifications will be valuable for their future industrial or academic contributions to the national scientific/technical infrastructure.

细菌将大气中的氮转化为氨，这对于地球上的生命来说是至关重要的。这是一个真正具有全球意义的反应。微生物使用固氮酶来进行这种化学反应。一个不寻常的铁，硫，钼和氮原子簇是酶内的反应位点。该簇如何工作是一个谜。我们提出了一个研究计划来探索这个奥秘。计算机模型表明，铁和氮原子之间的相互作用是固氮酶活性的核心;然而，这种化学，几乎没有先例。我们希望在受控合成系统中开发和研究这些相互作用，以了解它们的基本性质。然后我们可以将这些基本知识应用于分析和理解生物学。过程短期内，我们项目的成果将促进我们对基础无机和生物化学的理解。从长远来看，这项研究的见解有可能提高具有经济意义的工业化学过程的效率和能力。在该领域接受培训的学生将获得广泛的科学研究背景，并拥有一系列化学和物理技术的经验;这些资格将有助于他们今后对国家科学/技术基础设施作出工业或学术贡献。