Synthetic Inorganic Chemistry Related to the Nitrogenase Cofactor: Core Heteroligated Fe-S-X Cubanes and Higher Nuclearity Clusters

与固氮酶辅因子相关的合成无机化学：核心杂合 Fe-S-X 古巴烷和高核簇

• 批准号: RGPIN-2015-05210
• 负责人: Lee, Sonny
• 金额: $ 1.46万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632667
• 关键词: Synthetic; Inorganic; Chemistry; Related; Nitrogenase

The biological conversion of atmospheric nitrogen to ammonia is essential to life on Earth. The reaction is difficult to accomplish -- the equivalent industrial chemistry requires high temperatures and pressures to perform the conversion. Microbes use the nitrogenase enzyme system to achieve this reaction under mild, ambient conditions. At the heart of the enzyme is a cluster of iron, sulfur, molybdenum, and carbon atoms termed the iron-molybdenum cofactor that carries out this chemistry. How it does so is very much a mystery.

大气中氮向氨的生物转化对地球上的生命至关重要。这种反应很难完成--相当的工业化学需要高温和高压来进行转化。微生物利用固氮酶系统在温和的环境条件下实现这一反应。酶的核心是一簇铁、硫、钼和碳原子，称为铁钼辅因子，它执行这种化学反应。它如何做到这一点是一个谜。