Characterisation of the adiponectin receptors - AdipoR1 and AdipoR2

脂联素受体 - AdipoR1 和 AdipoR2 的表征

• 批准号: nhmrc : 1064353
• 负责人: A/Pr Jonathan Whitehead
• 金额: $ 29.68万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterisation-adiponectin-receptors-adipor1-adipor2/455114
• 关键词: Characterisation; adiponectin; receptors; AdipoR1; AdipoR2

The increasing incidence of cardiometabolic disease highlights an unmet need for novel therapeutic approaches. Greater understanding of the detail governing cardiometabolic function is required to provide a foundation to construct effective strategies. We will characterise 2 novel receptors that are important in the regulation and maintenance of cardiometabolic systems, seeking to identify strategies to enhance receptor, improve cardiometabolic function and reduce disease burden.

心脏代谢疾病的发生率的增加突出了对新型治疗方法的未满足的需求。需要对控制心脏代谢功能的细节有更多的了解，以提供构建有效策略的基础。我们将表征2种对心脏代谢系统调节和维护很重要的新型受体，以寻求确定增强受体，改善心脏代谢功能并减轻疾病负担的策略。