Elucidation of the Mechanism of IL-22-Mediated Suppression of β-Cell Stress in Diabetes
Elucidation of the Mechanism of IL-22-Mediated Suppression of β-Cell Stress in Diabetes
批准号:
nhmrc : GNT1108077
负责人:
A/Pr Jonathan Whitehead
金额:
$14.82万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 2017-12-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Pancreatic β-cells produce the hormone insulin that controls blood sugar. Type 2 diabetes is characterized by inability of stressed β-cells to make sufficient insulin to control blood sugar. We discovered that an immune factor, IL-22, protects β-cells from stress. Treatment of diabetic mice with IL-22 resolves all the major problems in diabetes. This project seeks to reveal the mechanisms by which IL-22 protects β-cells from stress, with potential for development of novel diabetes therapies.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Elucidation of the Mechanism of IL-22-Mediated Suppression of ?-Cell Stress in Diabetes
-
批准号:nhmrc : 1108077
-
项目类别:Project Grants
-
资助金额:$15.13万
-
财政年份:2016
-
负责人:A/Pr Jonathan Whitehead
-
依托单位:
Characterisation of the adiponectin receptors - AdipoR1 and AdipoR2
-
批准号:nhmrc : 1064353
-
项目类别:Project Grants
-
资助金额:$29.68万
-
财政年份:2014
-
负责人:A/Pr Jonathan Whitehead
-
依托单位:
Defining a new adipogenic pathway
-
批准号:nhmrc : 1047625
-
项目类别:Project Grants
-
资助金额:$30.95万
-
财政年份:2013
-
负责人:A/Pr Jonathan Whitehead
-
依托单位:
Inhibitors of Secretory Phospholipases in Diet Induced Obese Rats
-
批准号:nhmrc : 631534
-
项目类别:NHMRC Project Grants
-
资助金额:$38.74万
-
财政年份:2010
-
负责人:A/Pr Jonathan Whitehead
-
依托单位:
IMPDH and lipid accumulation
-
批准号:nhmrc : 401677
-
项目类别:NHMRC Project Grants
-
资助金额:$31.93万
-
财政年份:2007
-
负责人:A/Pr Jonathan Whitehead
-
依托单位:
Identification of insulin specific signal transduction pathways in adipocytes
-
批准号:nhmrc : 210170
-
项目类别:NHMRC Project Grants
-
资助金额:$30.14万
-
财政年份:2002
-
负责人:A/Pr Jonathan Whitehead
-
依托单位:
国内基金
海外基金
激发态氢气分子(e,2e)反应三重微分截面的高阶波恩近似和two-step mechanism修正
-
批准号:11104247
-
项目类别:青年科学基金项目
-
资助金额:25.0万元
-
批准年份:2011
-
负责人:杨则金
-
依托单位:
Research on the Rapid Growth Mechanism of KDP Crystal
-
批准号:10774081
-
项目类别:面上项目
-
资助金额:45.0万元
-
批准年份:2007
-
负责人:滕冰
-
依托单位: