Defining a new adipogenic pathway

定义新的脂肪形成途径

• 批准号: nhmrc : 1047625
• 负责人: A/Pr Jonathan Whitehead
• 金额: $ 30.95万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-new-adipogenic-pathway/111952
• 关键词: Defining; new; adipogenic; pathway

Obesity increases the risk of developing diseases such as heart disease and type 2 diabetes, however not all obese people develop such diseases. Obese subjects with small fat cells are typically healthier than those with fewer, large fat cells. The applicants have identified a novel pathway that promotes the generation of new fat cells. This project will increase understanding of this pathway and may, ultimately, lead to new therapies that manipulate fat cell number and reduce obesity related disease.

肥胖会增加患心脏病和2型糖尿病等疾病的风险，但是并非所有肥胖者都会出现这种疾病。肥胖的受试者通常比脂肪细胞较少的肥胖细胞更健康。申请人已经确定了一种促进新脂肪细胞产生的新途径。该项目将增加对这一途径的理解，最终可能导致新疗法操纵脂肪细胞数并减少与肥胖相关的疾病。