Characterisation of age and comorbidity-related defects in stem cell regenerative capacity during wound healing and adipose tissue engineering to facilitate clinical trials of tissue engineered breast reconstruction.

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Despite success with the production of new tissues and organs in laboratory animals, tissue engineering in humans remains elusive. Emerging evidence suggests that ageing and diseases such as diabetes can adversely affect human stem cell regenerative capacity. Characterizing the effects of ageing and disease on stem cells during tissue generation is the first step in reversing these effects, paving the way for the production of new tissues and organs for use in human clinical trials.