Characterisation of age and comorbidity-related defects in stem cell regenerative capacity during wound healing and adipose tissue engineering to facilitate clinical trials of tissue engineered breast reconstruction.

尽管在实验动物身上成功地制造出了新的组织和器官，但人体组织工程仍然难以捉摸。新出现的证据表明，衰老和糖尿病等疾病会对人类干细胞的再生能力产生不利影响。在组织生成过程中描述衰老和疾病对干细胞的影响是逆转这些影响的第一步，为生产用于人体临床试验的新组织和器官铺平了道路。

Despite success with the production of new tissues and organs in laboratory animals, tissue engineering in humans remains elusive. Emerging evidence suggests that ageing and diseases such as diabetes can adversely affect human stem cell regenerative capacity. Characterizing the effects of ageing and disease on stem cells during tissue generation is the first step in reversing these effects, paving the way for the production of new tissues and organs for use in human clinical trials.