Characterisation of eurl, a novel gene implicated in the etiology of abnormal brain development and intellectual disability

eurl 的特征，一种与大脑发育异常和智力障碍病因有关的新基因

• 批准号: nhmrc : 1028258
• 负责人: A/Pr Julian Heng
• 金额: $ 39.84万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterisation-eurl-novel-intellectual-disability/110621
• 关键词: Characterisation; eurl; novel; gene; implicated

Intellectual disability affects around one per cent of Australians, and can arise from genetic abnormalities during fetal life, such as through abnormal regulation of gene expression. We have identified a novel gene, known as eurl, which controls brain assembly as well as the ability of neurons to form functional connections within the brain. We will investigate how this novel gene controls brain development, and characterise eurl as a potential therapeutic target for learning and memory.

智力残疾影响着大约1%的澳大利亚人，可能是由于胎儿期的遗传异常，例如基因表达的异常调节。我们已经发现了一种新的基因，称为eurl，它控制大脑的组装以及神经元在大脑中形成功能连接的能力。我们将研究这种新基因如何控制大脑发育，并将其作为学习和记忆的潜在治疗靶点。