Characterisation of a novel PI3-kinase signal terminating enzyme in breast cancer.

乳腺癌中新型 PI3 激酶信号终止酶的表征。

• 批准号: nhmrc : 1010430
• 负责人: Prof Catriona Mclean
• 金额: $ 42.24万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterisation-novel-pi3-breast-cancer/109493
• 关键词: Characterisation; novel; PI3; kinase; signal

Breast cancer is the most common malignancy among females, affecting 1 in 9 women before the age of 85. Normally cells divide only when they receive a stimulus from a hormone or growth factor. The PI3K pathway which responds to these stimuli has been implicated in cancer where cells divide uncontrollably and invade surrounding tissue. We have identified a potential cancer suppressing gene, PIPP, which turns off PI3K growth signals. We aim to characterize the role of PIPP in breast cancer.

乳腺癌是女性中最常见的恶性肿瘤，影响 85 岁之前九分之一的女性。通常，细胞仅在受到激素或生长因子的刺激时才会分裂。对这些刺激作出反应的 PI3K 通路与癌症有关，在癌症中细胞不受控制地分裂并侵入周围组织。我们发现了一种潜在的癌症抑制基因 PIPP，它可以关闭 PI3K 生长信号。我们的目标是描述 PIPP 在乳腺癌中的作用。