The role of TCPTP in liver cancer

TCPTP在肝癌中的作用

• 批准号: nhmrc : 1047060
• 负责人: Prof Catriona Mclean
• 金额: $ 52.1万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-tcptp-liver-cancer/111903
• 关键词: role; TCPTP; liver; cancer

There are ~1.6 billion overweight adults worldwide & this is predicted to rise to 2.3 billion by 2015. In Australia > 2/3 of adults are overweight or obese. Obesity is a key factor in the progression of many human malignancies. Obesity poses the greatest risk for the development hepatocellular carcinoma (HCC), a deadly cancer refractory to nearly all available anti-cancer therapies. This application will delineate the molecular mechanisms by which obesity promotes HCC development.

全世界约有16亿成年人超重，预计到2015年将增至23亿。在澳大利亚，2/3的成年人超重或肥胖。肥胖是许多人类恶性肿瘤进展的关键因素。肥胖对肝细胞癌（HCC）的发展构成最大的风险，这是一种几乎所有可用的抗癌疗法都难以治愈的致命癌症。本申请将描述肥胖促进HCC发展的分子机制。