Role of the inositol polyphosphate 4-phosphatase type 2 in human breast cancer

2 型肌醇多磷酸 4-磷酸酶在人类乳腺癌中的作用

• 批准号: nhmrc : 606621
• 负责人: Prof Catriona Mclean
• 金额: $ 40.74万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-inositol-polyphosphate-breast-cancer/97382
• 关键词: Role; inositol; polyphosphate; phosphatase; type

Breast cancer is the most invasive cancer in females, affecting 1 in 9 women before the age of 85. Normally cells only divide when they receive a stimulus from a hormone or growth factor. The PI3K pathway responds to these stimuli and has been implicated in cancer when cells divide uncontrollably and invade surrounding tissue. We have identified a potential cancer suppressing gene, 4-ptase-2 that turns off the PI3K growth signals. We aim to characterize the role of 4-ptase-2 in breast cancer.

乳腺癌是女性中最具侵袭性的癌症，影响 85 岁之前的九分之一的女性。通常情况下，细胞只有在受到激素或生长因子的刺激时才会分裂。 PI3K 通路对这些刺激作出反应，并且当细胞不受控制地分裂并侵入周围组织时与癌症有关。我们发现了一种潜在的癌症抑制基因 4-ptase-2，它可以关闭 PI3K 生长信号。我们的目标是表征 4-ptase-2 在乳腺癌中的作用。