Characterisation of a novel signaling network that translates early-life respiratory infection into chronic lung disease

将生命早期呼吸道感染转化为慢性肺部疾病的新型信号网络的表征

• 批准号: nhmrc : 1072000
• 负责人: Dr Malcolm Starkey
• 金额: $ 21.1万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterisation-novel-signaling-lung-disease/455484
• 关键词: Characterisation; novel; signaling; network; translates

Bacterial and viral respiratory infections in early-life cause permanent damage to the lungs and reduce lung function in later life. They may also increase the risk of developing asthma and emphysema. These are substantial health problems in Australia. My project aims to identify how infections cause these effects. This will enable me to identify new therapeutic targets and develop new therapies for the prevention of chronic lung diseases.

生命早期的细菌和病毒性呼吸道感染会对肺部造成永久性损伤，并在以后的生活中降低肺功能。它们还可能增加患哮喘和肺气肿的风险。这些都是澳大利亚的健康问题。我的项目旨在确定感染如何导致这些影响。这将使我能够确定新的治疗靶点，并开发预防慢性肺部疾病的新疗法。