How innate lymphoid cells regulate mammalian lung development

先天淋巴细胞如何调节哺乳动物肺部发育

• 批准号: DE170100226
• 负责人: Dr Malcolm Starkey
• 金额: $ 26.03万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-06-30 至 2020-08-29
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE170100226
• 关键词: How; innate; lymphoid; cells; regulate

This project aims to determine the ability of a subset of lung resident immune cells to promote normal lung development through the regulation of stem cells. The lung is constantly exposed to countless environmental challenges including microbes. Mammals’ local immune systems protect the lung from these challenges. This is particularly important in early-life when the lung is still developing. However, impaired lung development affects humans and livestock, costing >$3 billion p.a. The intended outcome is to identify basic biological processes involved in normal mammalian lung development, which may lead to strategies to prevent chronic lung diseases in humans and animals.

该项目旨在确定肺部驻留免疫细胞的子集通过干细胞的调节促进正常肺部发育的能力。肺部不断暴露于包括微生物在内的无数环境挑战。哺乳动物的局部免疫系统可以保护肺部免受这些挑战。这在生命早期尤其重要，因为此时肺部仍在发育。然而，肺部发育受损会影响人类和牲畜，每年造成的损失超过 30 亿美元。预期的结果是确定正常哺乳动物肺部发育所涉及的基本生物过程，这可能会导致制定预防人类和动物慢性肺部疾病的策略。