Characterising the beneficial effects of estrogen on the prostate gland

描述雌激素对前列腺的有益作用

• 批准号: nhmrc : 545931
• 负责人: Prof Gail Risbridger
• 金额: $ 39.66万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterising-beneficial-effects-prostate-gland/77142
• 关键词: Characterising; beneficial; effects; estrogen; prostate

Prostate cancer is hormonally regulated and currently managed by androgen ablation. This application seeks to study the potential benefits of estrogen action for the treatment of prostate disease, including PCa. We will show estrogen hormone action causes prostatic cell death, targeting the stem-progenitor cells so the treated prostatic tissue does not regenerate. This project will provide pre-clinical proof of the efficacy of estrogenic compounds as a potential therapy for prostate disease.

前列腺癌是由激素调控的，目前通过雄激素消融术治疗。本应用旨在研究雌激素对前列腺疾病（包括前列腺癌）治疗的潜在益处。我们将展示雌激素激素作用导致前列腺细胞死亡，目标是干细胞祖细胞，因此治疗的前列腺组织不能再生。该项目将为雌激素化合物作为前列腺疾病的潜在治疗方法的有效性提供临床前证据。