Magnetic resonance imaging and potential measurements and analysis

摘要：功能磁共振成像（FMRI）和事件相关电位（ERP）记录是研究脑功能的两种方法。虽然常用，但关于测量的内容仍然存在许多问题。本研究的目的是为了更好地了解每一种方式测量的源的特征，它们的相关性，它们不同的敏感性，并证明在评估大脑功能时的互补性。在第一个系列的实验中，我们将系统地测试ERP逆解，并改进我们比较和整合ERP和FMRI成像结果的方法。在第二个系列的实验中，我们将测量正常受试者和患者的功能磁共振成像和ERP，以探索当刺激因一只眼睛的视觉系统缺陷而被修改或抑制时，ERP和功能磁共振成像发现的定位范围和行为相似。这将巩固我们对ERP和FMRI源位置如何联系的理解。在最后的一系列实验中，我们将进一步探索FMRI信号（负BOLD）在视觉刺激下的特定方面，以更好地理解该信号与ERP和正BOLD源位置之间的联系。意义：利用脑电图和功能磁共振成像对大脑中响应视觉刺激的活源进行成像，可以更好地理解这两种模式的相互作用、它们的效用以及由此产生的大脑功能。通过这项研究培养的学生需要成为医学物理学家和神经科学家。

Summary: Functional Magnetic Resonance Imaging (FMRI) and Event-Related Potential (ERP) recordings represent two methodologies to study brain function. Although commonly used many questions remain as to what is being measured. The aim of this study is to better understand the characteristics of the sources being measured with each modality, their correlation, their different sensitivities and to demonstrate the complementary nature in assessing brain function. In the first series of experiments we will systematically test ERP inverse solution and improve our means of comparing and integrating ERP and FMRI imaging results. In the second series of experiments we will measure FMRI and ERP in both normal subjects and patients to explore to what extend the localization as found by ERP and FMRI is and behaves similarly when stimuli are modified or suppressed because of defects in the visual system in one eye. This will solidify our understanding of how ERP and FMRI source locations are linked. In the final series of experiments we will further explore particular aspects of the FMRI signal (negative BOLD) signal in response to visual stimuli to better understand the connection between this signal and the ERP and positive BOLD source locations. Significance: Imaging active sources in the brain in response to visual stimuli with both EEG and FMRI leads to a better understanding of the interaction of these two modalities, their utility and consequently brain function. Students trained through this research are in demand as medical physicists and neuroscientists.