Magnetic resonance imaging and potential measurements and analysis

磁共振成像以及电势测量和分析

• 批准号: 376-2006
• 负责人: Stroink, Gerhard
• 金额: $ 3.13万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2007
• 资助国家: 加拿大
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=364386
• 关键词: Magnetic; resonance; imaging; potential; measurements

Summary: Functional Magnetic Resonance Imaging (FMRI) and Event-Related Potential (ERP) recordings represent two methodologies to study brain function. Although commonly used many questions remain as to what is being measured. The aim of this study is to better understand the characteristics of the sources being measured with each modality, their correlation, their different sensitivities and to demonstrate the complementary nature in assessing brain function. In the first series of experiments we will systematically test ERP inverse solution and improve our means of comparing and integrating ERP and FMRI imaging results. In the second series of experiments we will measure FMRI and ERP in both normal subjects and patients to explore to what extend the localization as found by ERP and FMRI is and behaves similarly when stimuli are modified or suppressed because of defects in the visual system in one eye. This will solidify our understanding of how ERP and FMRI source locations are linked. In the final series of experiments we will further explore particular aspects of the FMRI signal (negative BOLD) signal in response to visual stimuli to better understand the connection between this signal and the ERP and positive BOLD source locations. Significance: Imaging active sources in the brain in response to visual stimuli with both EEG and FMRI leads to a better understanding of the interaction of these two modalities, their utility and consequently brain function. Students trained through this research are in demand as medical physicists and neuroscientists.

摘要：功能磁共振成像(FMRI)和事件相关电位(ERP)记录是研究脑功能的两种方法。尽管普遍使用，但对于正在衡量的是什么，仍然存在许多问题。这项研究的目的是为了更好地了解每种模式测量的信号源的特征、它们的相关性、它们的不同敏感性，并证明在评估脑功能方面的互补性。在第一系列实验中，我们将系统地测试ERP逆解，并改进我们比较和整合ERP和fMRI成像结果的方法。在第二系列实验中，我们将在正常受试者和患者中测量fMRI和ERP，以探索当由于一只眼睛的视觉系统缺陷而修改或抑制刺激时，ERP和fMRI发现的定位程度和行为相似。这将巩固我们对ERP和fMRI信号源位置如何联系的理解。在最后一系列实验中，我们将进一步探索fMRI信号(负BOLD)信号对视觉刺激的反应的特定方面，以更好地理解该信号与ERP和正BOLD来源位置之间的联系。意义：用EEG和fMRI对大脑中的活动源进行成像，以响应视觉刺激，可以更好地了解这两种模式的相互作用，它们的用途，从而更好地了解大脑功能。通过这项研究培养的学生需要医学物理学家和神经学家。