Ultrasound based multiphysics imaging modalities: modelling, analysis and biomedical applications

基于超声的多物理场成像模式：建模、分析和生物医学应用

• 批准号: 125876-2006
• 负责人: Bertrand, Michel
• 金额: $ 2.62万
• 依托单位: École Polytechnique de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2006
• 资助国家: 加拿大
• 起止时间: 2006-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=339268
• 关键词: Ultrasound; based; multiphysics; imaging; modalities

This proposal is about the development of new methods to study biological tissues and fluids using image modeling and analysis for multiphysics-based imaging modalities. By multiphysics-based imaging it is meant imaging modalities exploiting the fact that two physical effects either co-exist or interact with each other so that together they provide a new window to observe the biological tissue or fluid. Three examples we propose to study are given. A first example would be the observation of the electric field generated by a tissue in a magnetic field while the tissue is being simultaneously insonified.  Here the ultrasound would set ions in motion, and ions in motion in a magnetic field produce the observed electric potential distribution; this distribution is therefore a spatio-temporal signal determined by the emitted acoustic signal, the acoustic properties of the medium, the electrical properties of the tissue and the generated magnetic field itself. A second example uses acousto-optic interactions. Here an ultrasound signal is used to modulate an optical signal that propagates in the tissue. With appropriated time-gating the modulated optical signal is identified as being issued from a specific tissue region. The third example concerns the use of acoustic radiation force to deform a tissue and determine its stiffness using speckle motion estimation. Here the physics of continuum mechanics coupled to acoustics.   The purpose of this research is ultimately to assess certain fundamental physical properties of biological materials. To develop this approach, the research project is divided in three parts: image formation modeling, signal analysis and phantom experiments. The method is anticipated to provide a significant advance in medical ultrasonic imaging and may have potential applications in other engineering areas that involve a coherent imaging modality such as radar and laser imaging.

该提案是关于使用基于多物理场的成像模式的图像建模和分析来开发研究生物组织和流体的新方法。基于多物理场的成像是指利用两种物理效应共存或相互作用的事实的成像方式，以便它们一起提供观察生物组织或流体的新窗口。给出了我们建议研究的三个例子。第一个例子是在磁场中组织同时被声穿透时观察组织产生的电场。  在这里，超声波会使离子运动，而在磁场中运动的离子会产生观察到的电势分布；因此，该分布是由发射的声信号、介质的声学特性、组织的电特性和生成的磁场本身确定的时空信号。第二个例子使用声光相互作用。这里，超声信号用于调制在组织中传播的光信号。通过适当的时间选通，调制光信号被识别为从特定组织区域发出。第三个示例涉及使用声辐射力使组织变形并使用散斑运动估计确定其刚度。这里是连续介质力学与声学的结合。   这项研究的目的最终是评估生物材料的某些基本物理特性。为了开发这种方法，该研究项目分为三个部分：图像形成建模、信号分析和模型实验。该方法预计将在医学超声成像方面取得重大进展，并且可能在涉及相干成像模式（例如雷达和激光成像）的其他工程领域具有潜在的应用。