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Simulation-based Scale-up of Bioreactors using Computational Multiphysics

使用计算多物理场进行基于模拟的生物反应器放大

基本信息

批准号：
523521-2018
负责人：
Abukhdeir, NasserMohieddin
金额：
$ 1.82万
依托单位：
University of Waterloo
依托单位国家：
加拿大
项目类别：
Engage Grants Program
财政年份：
2018
资助国家：
加拿大
起止时间：
2018-01-01 至 2019-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=643397
关键词：
Simulation based Scale up Bioreactors

项目摘要

The use of bioreactors (biological reactors) is pervasive in biological manufacturing, where the cultivation of**microorganisms is required for the production of antibiotics, vaccines, and biological theraputics. The**biological processes involved in bioreactors results in the design and scale-up of bioreactors presenting extreme**challenges in that they involve coupled multiphase multiphysics including mass transport, interphase mass**exchange, biological reaction, multiphase hydrodynamics, and**energy transport. Consequently, commercial-scale bioreactors are mainly batch reactors with relatively small**physical scales, compared to large-scale continuous reactors in traditional bulk chemicals industry.**Improvements in engineering design processes for bioreactors, specifically scale-up and optimization, are key**priorities in biological manufacturing. Scale-up of pilot-scale bioreactors for newly developed antibiotics and**vaccines would result in more rapidly bringing them to market, in addition to production in increased quantities**at lower costs. Within this context, this research project involves computational research for the optimization**and design of bioreactors used for vaccine production. This will be accomplished through the use of**cutting-edge multiphase models, numerical methods, and specialized expertise in the understanding of these**concepts.

生物反应器（生物反应器）的使用在生物制造中是普遍的，其中微生物的培养是生产抗生素，疫苗和生物治疗剂所必需的。生物反应器中涉及的生物过程导致生物反应器的设计和放大呈现极端的挑战，因为它们涉及耦合的多相多物理场，包括质量传输、相间质量交换、生物反应、多相流体动力学和能量传输。因此，与传统散装化学品工业中的大规模连续反应器相比，商业规模的生物反应器主要是具有相对较小 ** 物理规模的间歇反应器。生物反应器工程设计过程的改进，特别是放大和优化，是生物制造的关键优先事项。扩大用于新开发的抗生素和 ** 疫苗的中试规模生物反应器的规模，除了以较低的成本增加产量 ** 外，还可以更快地将其推向市场。在此背景下，该研究项目涉及用于疫苗生产的生物反应器的优化 ** 和设计的计算研究。这将通过使用尖端的多相模型、数值方法和理解这些概念的专业知识来实现。