Characterization of a novel family of LIM-only proteins; role in skeletal muscle differentiation.

该项目旨在研究骨骼肌中一个新的相关蛋白质家族的作用。其中一种蛋白质已被证明在肌肉癌中缺乏。这些蛋白质对肌肉的发育和正常功能非常重要。相关蛋白质已被证明与动物心力衰竭有关。这些蛋白质也可能与引起肌营养不良的蛋白质相互作用。我们在骨骼肌中发现了一个新的蛋白质家族。这些蛋白质含有所谓的LIM结构域，其介导与其他蛋白质的结合。这项研究旨在确定这些蛋白质如何影响骨骼肌发育以及这些蛋白质异常水平的后果。这可能会导致对心力衰竭，肌肉癌和肌肉萎缩症的机制的见解。

This project aims to study the role of a new family of related proteins in skeletal muscle. One of these proteins has been shown to be deficient in muscle cancers. These proteins are important for the development and normal functioning of muscle. Related proteins have been shown to be linked with heart failure in animals. These proteins also potentially interact with proteins causing muscular dystrophy. We have identified a new family of proteins in skeletal muscle. These proteins contain so-called LIM domains, which mediate binding to other proteins. This study proposes to determine how these proteins influence skeletal muscle development and the consequences of abnormal levels of these proteins. This may lead to insights into the mechanism of cardiac failure, muscle cancers and muscular dystrophy.