The function and regulation of myogenic progenitor populations in aging and exercise

衰老与骨骼肌质量和力量的丧失有关，统称为骨质疏松症。骨质疏松症的常见后果包括跌倒导致的骨折、独立性和制度化的丧失，最终导致生活质量下降。尽管有许多关于骨质疏松症的基本机制(S)的理论，但没有一种理论完全可以接受或解释骨质疏松症过程的所有方面。骨骼肌是一种独特的组织，它与一群具有生成新肌肉能力的细胞(卫星细胞和干细胞)有关。骨骼肌质量的维持依赖于这些细胞在整个生命过程中的持续运行。我的研究计划建议研究卫星细胞和干细胞的丰度随年龄的增长以及控制卫星细胞和干细胞功能的调节途径，因为我认为这些成肌祖细胞群可能是年龄相关性骨质疏松症基本机制(S)的组成部分。此外，为了更好地了解可能影响卫星和干细胞调控途径的信号，我的研究计划将检查老年人的运动训练，以此作为维持有效卫星细胞和干细胞功能的策略。我们将确定保持这些细胞功能所需的机制是否在衰老过程中保持，如果不是，在衰老过程中到底出了什么问题。最终，提高生活质量，延长独立生活时间是我们老龄化人口的目标。我的研究计划旨在解开骨骼肌衰老的奥秘，并为其他人提供方向(通过提供有趣的分子、细胞和生化数据)，以扩展这些结果，以开发与年龄相关的石棺减少的对策。

Aging is associated with a loss of skeletal muscle mass, and strength, which is collectively referred to as sarcopenia.  Common consequences of sarcopenia include bone fractures due to falls, a loss of independence and institutionalization, ultimately leading to a reduced quality of life.  Despite many theories regarding the fundamental mechanism(s) underlying sarcopenia, none is entirely acceptable or explains all aspects of the sarcopenic process. Skeletal muscle is a unique tissue that is associated with a population of cells (satellite cells and stem cells) with the ability to make new muscle.  The maintenance of skeletal muscle mass is dependent on the sustained operation of these cells throughout life.  My research program proposes to examine the abundance of satellite cell and stem cells with aging as well as the regulatory pathways that govern satellite cell and stem cell function, as I believe that these myogenic progenitor populations may be a component of the fundamental mechanism(s) of age-related sarcopenia.  In addition, to better understand the signals that may influence satellite and stem cell regulatory pathways my research program will examine exercise training in older adults as a strategy to maintain efficient satellite cell and stem cell function.  We will identify whether the machinery necessary to keep these cells functioning is maintained during aging, and if not, what exactly is going wrong during the aging process.  . Ultimately, improved quality of life, with prolonged independent living is the goal for our aging population.  My research program is aimed at unraveling the mysteries of skeletal muscle aging, and providing others with the direction (by providing intriguing molecular, cellular, and biochemical data) to extend these results for the development of countermeasures for age-related sarcopenia.