Human muscle stem cell physiology: Characterization, regulation and function.

人类肌肉干细胞生理学：特征、调节和功能。

• 批准号: RGPIN-2016-05633
• 负责人: Parise, Gianni
• 金额: $ 2.55万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630776
• 关键词: Human; muscle; stem; cell; physiology

The processes that govern muscle adaptation and repair are highly complex and involve interactions between multiple organs, tissues, cells, sub cellular organelles and a host of coordinated molecular signaling events. Many of these interactions/events remain to be elucidated. It is not yet clear how satellite cells interact with their environment to promote adaptation/repair or whether specific relationships between satellite cells and other structures, such as capillaries, are important in regulating satellite cell function. Furthermore, although satellite cells are considered to be the primary stem cell population in skeletal muscle there is evidence in rodents suggesting the presence of other stem/progenitor populations that have never even been described in human skeletal muscle, but may nonetheless be important in supporting skeletal muscle growth and adaptation.

支配肌肉适应和修复的过程是高度复杂的，涉及多个器官、组织、细胞、亚细胞细胞器和一系列协调的分子信号事件之间的相互作用。其中许多相互作用/事件仍有待阐明。目前尚不清楚卫星细胞如何与环境相互作用以促进适应/修复，也不清楚卫星细胞与毛细血管等其他结构之间的特定关系在调节卫星细胞功能方面是否重要。此外，尽管卫星细胞被认为是骨骼肌中的主要干细胞群体，但在啮齿类动物中，有证据表明存在其他干祖细胞群体，这些群体甚至从未在人类骨骼肌中被描述过，但仍可能在支持骨骼肌生长和适应方面发挥重要作用。