Polymer-grafted membrane-mimetic surfaces: lateral structure and interactions with dissolved biomolecules

聚合物接枝膜模拟表面：横向结构以及与溶解生物分子的相互作用

• 批准号: 298412-2007
• 负责人: Tsoukanova, Valeria
• 金额: $ 2.7万
• 依托单位: York University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2007
• 资助国家: 加拿大
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=361307
• 关键词: Polymer; grafted; membrane; mimetic; surfaces

An ongoing effort of biomaterials research is concerned with the engineering of bio-non-fouling membrane-mimetic surfaces. Such surfaces can be formed by introducing molecules grafted with hydrophilic polymers into self-assembled lipid matrixes (monolayers, bilayers, liposomes). Our study will be focused on how various lipids and polymer-grafted molecules can be assembled together to produce sufficiently stable membrane-mimetic surfaces with a well-defined structure of the grafted polymer layer. By performing state-of-the-art surface characterizations, the lateral structure and local properties of polymer-grafted membrane-mimetic surfaces will be examined. Then, the ultimate characterization of the surface structure will be accomplished by studying the accessibility of various locations on the surface to dissolved biomolecules. The knowledge obtained from these studies will be used to derive composition/structure and structure/property relationships that can serve as guidelines for the rational design of bio-non-fouling membrane-mimetic layers on the surface of implanted medical devises and sterically stabilized liposomes.

仿生膜表面工程是目前生物材料研究的热点之一。这种表面可以通过将亲水聚合物接枝的分子引入自组装的脂质基质（单层、双层、脂质体）中形成。我们的研究将集中在如何将各种脂质和聚合物接枝分子组装在一起，以产生具有明确接枝聚合物层结构的足够稳定的膜模拟表面。通过执行最先进的表面表征，横向结构和局部性质的聚合物接枝膜模拟表面将被检查。然后，通过研究表面不同位置对溶解生物分子的可及性来完成表面结构的最终表征。从这些研究中获得的知识将用于推导组成/结构和结构/性质关系，这些关系可以作为合理设计植入医疗器械表面的生物无污染膜模拟层和空间稳定脂质体的指导方针。