Polymer-grafted membrane-mimetic surfaces: lateral structure and interactions with dissolved biomolecules

生物材料研究的一个持续努力与生物无污染膜仿生表面的工程有关。这种表面可以通过将与亲水性聚合物接枝的分子引入自组装的脂质基质(单层、双层、脂质体)来形成。我们的研究将集中在如何将各种脂类和聚合物接枝分子组装在一起，以产生具有明确接枝聚合物层结构的足够稳定的膜仿生表面。通过进行最先进的表面表征，将检查聚合物接枝薄膜模拟表面的横向结构和局部性质。然后，表面结构的最终表征将通过研究表面上不同位置对溶解生物分子的可访问性来完成。从这些研究中获得的知识将被用来推导组成/结构和结构/性能关系，这些关系可以作为合理设计植入式医疗器械和空间稳定脂质体表面生物无污染膜仿真层的指导方针。

An ongoing effort of biomaterials research is concerned with the engineering of bio-non-fouling membrane-mimetic surfaces. Such surfaces can be formed by introducing molecules grafted with hydrophilic polymers into self-assembled lipid matrixes (monolayers, bilayers, liposomes). Our study will be focused on how various lipids and polymer-grafted molecules can be assembled together to produce sufficiently stable membrane-mimetic surfaces with a well-defined structure of the grafted polymer layer. By performing state-of-the-art surface characterizations, the lateral structure and local properties of polymer-grafted membrane-mimetic surfaces will be examined. Then, the ultimate characterization of the surface structure will be accomplished by studying the accessibility of various locations on the surface to dissolved biomolecules. The knowledge obtained from these studies will be used to derive composition/structure and structure/property relationships that can serve as guidelines for the rational design of bio-non-fouling membrane-mimetic layers on the surface of implanted medical devises and sterically stabilized liposomes.