Polymer-grafted membrane-mimetic surfaces: lateral structure and interactions with dissolved biomolecules

生物材料研究的一个正在进行的努力是与生物无污染膜模拟表面的工程有关。这样的表面可以通过将接枝有亲水性聚合物的分子引入自组装脂质基质（单层、双层、脂质体）中来形成。我们的研究将集中在如何将各种脂质和聚合物接枝分子组装在一起，以产生足够稳定的膜模拟表面，具有明确定义的接枝聚合物层结构。通过执行国家的最先进的表面表征，聚合物接枝膜模拟表面的横向结构和局部性质将被检查。然后，表面结构的最终表征将通过研究表面上不同位置对溶解的生物分子的可及性来完成。从这些研究中获得的知识将用于推导组成/结构和结构/性质关系，这些关系可以作为植入式医疗器械和空间稳定脂质体表面上的生物无污染膜模拟层的合理设计的指南。

An ongoing effort of biomaterials research is concerned with the engineering of bio-non-fouling membrane-mimetic surfaces. Such surfaces can be formed by introducing molecules grafted with hydrophilic polymers into self-assembled lipid matrixes (monolayers, bilayers, liposomes). Our study will be focused on how various lipids and polymer-grafted molecules can be assembled together to produce sufficiently stable membrane-mimetic surfaces with a well-defined structure of the grafted polymer layer. By performing state-of-the-art surface characterizations, the lateral structure and local properties of polymer-grafted membrane-mimetic surfaces will be examined. Then, the ultimate characterization of the surface structure will be accomplished by studying the accessibility of various locations on the surface to dissolved biomolecules. The knowledge obtained from these studies will be used to derive composition/structure and structure/property relationships that can serve as guidelines for the rational design of bio-non-fouling membrane-mimetic layers on the surface of implanted medical devises and sterically stabilized liposomes.