Role of hip1 and hip1r in endocytosis, structure-function analysis

hip1 和 hip1r 在内吞作用、结构功能分析中的作用

• 批准号: 342200-2007
• 负责人: LegendreGuillemin, Valérie
• 金额: $ 2.26万
• 依托单位: Université du Québec à Chicoutimi
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2007
• 资助国家: 加拿大
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=361710
• 关键词: Role; hip1; hip1r; endocytosis; structure

Communication between cells and their environment is important. At the cell surface, proteins are expressed and are regulating cell function. Their surface expression need to be controled because these proteins are involved in the uptake of small molecules including ions and nutrients that are necessary for cell function. Also, these surface proteins (also called receptors) are involved in virus uptake into cells. One way to regulate cell surface expression of these receptors is endocytosis. Endocytosis is a complex process that allow receptors to enter inside the cell. Mechanism of endocytosis involved a variety of protein complexes that play a role at different step and time. One of the challenge of cell biology is to understand the function of each protein involved in this process and also to identify new proteins. My research program centers on the understanding of the function of two proteins  important in the mechanism of endocytosis.

细胞和环境之间的交流很重要。在细胞表面，蛋白质表达并调节细胞功能。它们的表面表达需要控制，因为这些蛋白质参与小分子的摄取，包括离子和细胞功能所必需的营养物质。此外，这些表面蛋白（也称为受体）参与了病毒进入细胞的摄取。调节这些受体的细胞表面表达的一种方法是内吞作用。内吞作用是一个允许受体进入细胞内部的复杂过程。内吞作用的机制涉及多种蛋白质复合物，它们在不同的步骤和时间起作用。细胞生物学的挑战之一是了解参与这一过程的每种蛋白质的功能，并识别新的蛋白质。我的研究项目集中在了解在内吞作用机制中重要的两种蛋白质的功能。