Role of hip1 and hip1r in endocytosis, structure-function analysis

细胞与环境之间的沟通是非常重要的。在细胞表面，蛋白质表达并调节细胞功能。它们的表面表达需要被控制，因为这些蛋白质参与细胞功能所必需的小分子（包括离子和营养物质）的摄取。此外，这些表面蛋白（也称为受体）参与病毒摄取到细胞中。调节这些受体的细胞表面表达的一种方式是内吞作用。内吞作用是一个复杂的过程，允许受体进入细胞内部。内吞作用的机制涉及多种蛋白质复合物，它们在不同的步骤和时间发挥作用。细胞生物学的挑战之一是了解参与这一过程的每种蛋白质的功能，并识别新的蛋白质。我的研究项目集中在对两种在胞吞作用机制中重要的蛋白质的功能的理解上。

Communication between cells and their environment is important. At the cell surface, proteins are expressed and are regulating cell function. Their surface expression need to be controled because these proteins are involved in the uptake of small molecules including ions and nutrients that are necessary for cell function. Also, these surface proteins (also called receptors) are involved in virus uptake into cells. One way to regulate cell surface expression of these receptors is endocytosis. Endocytosis is a complex process that allow receptors to enter inside the cell. Mechanism of endocytosis involved a variety of protein complexes that play a role at different step and time. One of the challenge of cell biology is to understand the function of each protein involved in this process and also to identify new proteins. My research program centers on the understanding of the function of two proteins important in the mechanism of endocytosis.