mRNA surveillance in human genetic disease: Molecular determinants of nonsense-mediated mRNA decay

人类遗传疾病中的 mRNA 监测：无义介导的 mRNA 衰变的分子决定因素

• 批准号: nhmrc : 1044169
• 负责人: A/Pr Shireen Lamande
• 金额: $ 24.76万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mrna-surveillance-human-mrna-decay/111635
• 关键词: mRNA; surveillance; human; genetic; disease

In about 1/3 of inherited disorders the mutations introduce an abnormal stop signal into the gene so that cells risk producing truncated or erroneous proteins. To prevent this cells have developed control surveillance mechanisms called Nonsense Mediated m

在大约1/3的遗传性疾病中，突变将异常的终止信号引入基因，使得细胞有产生截短或错误蛋白质的风险。为了防止这种情况，细胞已经发展出一种称为无意义介导的控制监视机制。