The calcium channel TRPV4 in skeletal development and arthritis

骨骼发育和关节炎中的钙通道 TRPV4

• 批准号: nhmrc : 1025715
• 负责人: A/Pr Shireen Lamande
• 金额: $ 45.55万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/calcium-channel-trpv4-development-arthritis/110446
• 关键词: calcium; channel; TRPV4; skeletal; development

We have discovered that mutations in a calcium channel gene, TRPV4, cause an inherited osteoarthritis in the hands and feet. This work suggests that TRPV4 may be important in osteoarthritis and suggests the exciting possibility that modulating TRPV4 activity may provide a new therapeutic approach for arthritis. We will study how and why the mutations disrupt channel function and study mouse models to see if they are more or less susceptible to arthritis.

我们发现，钙通道基因TRPV4的突变会导致手和脚的遗传性骨关节炎。这项工作表明TRPV4可能在骨关节炎中很重要，并表明调节TRPV4活性可能为关节炎提供新的治疗方法。我们将研究这些突变如何以及为何扰乱通道功能，并研究小鼠模型，看看它们是否或多或少对关节炎敏感。