Can nanoparticles give an old iron chelator a new life? — Development of targeted polymeric nanoparticles with long half-lives to treat iron overload diseases

纳米粒子能否赋予旧的铁螯合剂新生命？

• 批准号: nhmrc : 1112258
• 金额: $ 21.61万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/nanoparticles-an-old-overload-diseases/663210
• 关键词: nanoparticles; give; old; iron; chelator

Iron loading disorders (such as thalassaemia) represent an important class of human disease. As part of the treatment for these diseases, the iron needs to be removed and this is often done using iron-binding drugs known as iron chelators. Current chelators are not ideal due to side effects or onerous delivery methods. The goal of this project is to use nanotechnology to develop more effective ways of delivering chelators to improve their effectiveness and reduce toxicity.

铁负荷障碍（如地中海贫血）代表一类重要的人类疾病。作为治疗这些疾病的一部分，铁需要被去除，这通常是使用铁结合药物称为铁螯合剂。目前的螯合剂由于副作用或繁琐的递送方法而不是理想的。该项目的目标是利用纳米技术开发更有效的方法来提供螯合剂，以提高其有效性并降低毒性。