Improvement of bioperformance at nanoscale level

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Nanotechnology is likely to evolve rapidly into further complexity where nanorobots that consist of many different nanomaterials will be made. Recently, nanomaterials have received an enormous amount of attention to create new types of tools for life sciences. In our Laboratory, we selected two smart nanomaterials which can be non-invasively driven by an external power source such Magnetic Resonance Imaging. Theses nanomaterials are Carbon NanoTubes (CNTs) and Magnetic NanoParticles (MNP). An exciting property of CNTs is their ability to efficiently convert electrical energy into mechanical energy. Both nanomaterials have many interesting properties that will eventually lead to a variety of applications as nanodelivery system, nanomuscles and actuators for nanorobots. The main objectives of the proposed project are: identify the key physicochemical properties of CNTs at the molecular level that govern protein adsorption patterns and develop a fabrication protocol that leads to a favourable biological response. Validate the use of carbon nanotubes for medical applications via the optimization of their biocompatibility by surface functionalization and improvements in the formulation protocol. We plan to develop new CNT- based biomaterials as a support for tissue regeneration and a low-density lipoprotein telescopic nanograsper.