Nano/Microscale Medical Devices

我们的研究项目是我们之前工作的延续，旨在为纳米医学和再生医学开发纳米/微设备。因此，近年来，我们开发了用于基因控释的壳聚糖纳米颗粒和基于碳纳米管的神经再生复合材料。最近，我们合作开发了一种磁性驱动的纳米机器人，用于系统递送药物，磁性驱动的纳米载体用于通过肺部递送一氧化氮。我们已经建立了纳米级表面分析技术，以及适用于纳米材料的生物相容性和血液相容性评估方法。正在进行的关于物理化学性质和生物反应之间的相关性的研究工作应该能更好地理解蛋白质被纳米粒子“电晕”吸附的现象。我们未来几年的目标是：1)表征三种具有纳米医学潜力的超顺磁性纳米颗粒（Fe3O4，磁小体，Fe7C3）的物理化学性质和磁性（热疗）；2)研究这些SPMNPs与蛋白质的相互作用机制和纳米毒性机制（活性氧、离子溶解等），以阐明其生物相容性和血液相容性；3)纳米/微医疗器械的发展：(1)SPMNPs的功能化，用于附着和控释一氧化氮，用于抗菌和抗癌治疗；（ii） SPMNPs功能化以控制抗疼痛肽的释放；（iii） SPMNPs功能化以从血液中捕获和去除低密度脂蛋白（ldl）；4)研究暴露于静态磁场和射频电磁场对SPMNPs毒性的影响，因为这些纳米/微器件是由磁共振成像（MRI）驱动的。

Our research program is the continuation of our previous work aiming to develop nano/micro devices for nanomedicine and regenerative medicine. Thus, in recent years, we have developed chitosan nanoparticles for controlled release of genes and composites based on carbon nanotubes for nerve regeneration. Recently, we collaborated to develop a magnetically driven nanorobot to deliver drugs systemically and magnetically driven nanovector for delivering nitric oxide via the lungs. We have established techniques for surface analysis at the nanoscale as well as methods for the evaluation of biocompatibility and hemocompatibility suited for nanomaterials. Ongoing work on the studies of correlation between physiochemical properties and biological response should provide a better understanding of the phenomenon of protein adsorption to nanoparticles called the "corona". Our objectives for the coming years are as follows: 1) Characterization of physicochemical properties and magnetic properties (hyperthermia) of three superparamagnetic nanoparticles (SPMNPs) (Fe3O4, magnetosomes, Fe7C3) with great potential in nanomedicine; 2) Study of the mechanisms of interaction of these SPMNPs with proteins and nanotoxicity mechanisms (reactive oxygen species, ionic dissolution, ...) in order to elucidate their biocompatibility and hemocompatibility; 3) Development of nano/micro medical devices: (i) functionalization of SPMNPs for attachment and controlled release of nitric oxide for antibacterial and anticancer treatments; (ii) Functionalization of SPMNPs for controlled release of anti-pain peptides; (iii) Functionalization of SPMNPs to capture and remove low-density lipoproteins (LDLs) from blood; 4) Study of the effects of exposure to both static magnetic and radiofrequency electromagnetic fields on the toxicity of SPMNPs, since these nano/micro devices are driven by magnetic resonance imaging (MRI).