Nano/Microscale Medical Devices

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Our research program is the continuation of our previous work aiming to develop nano/micro devices for nanomedicine and regenerative medicine. Thus, in recent years, we have developed chitosan nanoparticles for controlled release of genes and composites based on carbon nanotubes for nerve regeneration. Recently, we collaborated to develop a magnetically driven nanorobot to deliver drugs systemically and magnetically driven nanovector for delivering nitric oxide via the lungs. We have established techniques for surface analysis at the nanoscale as well as methods for the evaluation of biocompatibility and hemocompatibility suited for nanomaterials. Ongoing work on the studies of correlation between physiochemical properties and biological response should provide a better understanding of the phenomenon of protein adsorption to nanoparticles called the "corona". Our objectives for the coming years are as follows: 1) Characterization of physicochemical properties and magnetic properties (hyperthermia) of three superparamagnetic nanoparticles (SPMNPs) (Fe3O4, magnetosomes, Fe7C3) with great potential in nanomedicine; 2) Study of the mechanisms of interaction of these SPMNPs with proteins and nanotoxicity mechanisms (reactive oxygen species, ionic dissolution, ...) in order to elucidate their biocompatibility and hemocompatibility; 3) Development of nano/micro medical devices: (i) functionalization of SPMNPs for attachment and controlled release of nitric oxide for antibacterial and anticancer treatments; (ii) Functionalization of SPMNPs for controlled release of anti-pain peptides; (iii) Functionalization of SPMNPs to capture and remove low-density lipoproteins (LDLs) from blood; 4) Study of the effects of exposure to both static magnetic and radiofrequency electromagnetic fields on the toxicity of SPMNPs, since these nano/micro devices are driven by magnetic resonance imaging (MRI).