Nano/Microscale Medical Devices

纳米/微米级医疗器械

• 批准号: 4883-2013
• 负责人: Yahia, LHocine
• 金额: $ 1.82万
• 依托单位: École Polytechnique de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=520747
• 关键词: Nano; Microscale; Medical; Devices

Our research program is the continuation of our previous work aiming to develop nano/micro devices for nanomedicine and regenerative medicine. Thus, in recent years, we have developed chitosan nanoparticles for controlled release of genes and composites based on carbon nanotubes for nerve regeneration. Recently, we collaborated to develop a magnetically driven nanorobot to deliver drugs systemically and magnetically driven nanovector for delivering nitric oxide via the lungs. We have established techniques for surface analysis at the nanoscale as well as methods for the evaluation of biocompatibility and hemocompatibility suited for nanomaterials. Ongoing work on the studies of correlation between physiochemical properties and biological response should provide a better understanding of the phenomenon of protein adsorption to nanoparticles called the "corona". Our objectives for the coming years are as follows: 1) Characterization of physicochemical properties and magnetic properties (hyperthermia) of three superparamagnetic nanoparticles (SPMNPs) (Fe3O4, magnetosomes, Fe7C3) with great potential in nanomedicine; 2) Study of the mechanisms of interaction of these SPMNPs with proteins and nanotoxicity mechanisms (reactive oxygen species, ionic dissolution, ...) in order to elucidate their biocompatibility and hemocompatibility; 3) Development of nano/micro medical devices: (i) functionalization of SPMNPs for attachment and controlled release of nitric oxide for antibacterial and anticancer treatments; (ii) Functionalization of SPMNPs for controlled release of anti-pain peptides; (iii) Functionalization of SPMNPs to capture and remove low-density lipoproteins (LDLs) from blood; 4) Study of the effects of exposure to both static magnetic and radiofrequency electromagnetic fields on the toxicity of SPMNPs, since these nano/micro devices are driven by magnetic resonance imaging (MRI).

我们的研究计划是我们以前工作的延续，旨在开发纳米医学和再生医学的纳米/微型器件。因此，近年来，我们开发了用于基因控释的壳聚糖纳米颗粒和用于神经再生的基于碳纳米管的复合材料。最近，我们合作开发了一种磁驱动的纳米机器人来全身递送药物，以及磁驱动的纳米载体来通过肺部递送一氧化氮。我们已经建立了纳米级的表面分析技术以及适用于纳米材料的生物相容性和血液相容性评价方法。正在进行的工作的相关性研究的理化性质和生物反应，应提供一个更好的理解的现象，蛋白质吸附到纳米粒子称为“冠”。本论文的主要工作如下：1）研究三种在纳米医学领域具有巨大应用潜力的超顺磁性纳米粒子（Fe_3O_4，magnetosomes，Fe_7C_3）的物理化学性质和磁学性质（热疗）; 2）研究这些超顺磁性纳米粒子与蛋白质的相互作用机制和纳米毒性机制（活性氧，离子溶解等）。为了阐明它们的生物相容性和血液相容性; 3）纳米/微型医疗装置的开发：（i）SPMNP的功能化，用于附着和控制释放一氧化氮，用于抗菌和抗癌治疗;（ii）SPMNP的功能化，用于控制释放抗疼痛肽;（iii）SPMNP的功能化，用于从血液中捕获和去除低密度脂蛋白（LDL）; 4）研究暴露于静态磁场和射频电磁场对SPMNP毒性的影响，因为这些纳米/微米器件由磁共振成像（MRI）驱动。