Improvement of bioperformance at nanoscale level

纳米技术可能会迅速发展到更加复杂的地步，届时将制造出由许多不同的纳米材料组成的纳米机器人。近年来，纳米材料在为生命科学创造新型工具方面受到了极大的关注。在我们的实验室中，我们选择了两种智能纳米材料，它们可以由外部电源（如磁共振成像）非侵入性驱动。这些纳米材料是碳纳米管（CNTs）和磁性纳米颗粒（MNP）。碳纳米管的一个令人兴奋的特性是它们能够有效地将电能转化为机械能。这两种纳米材料都有许多有趣的特性，最终将导致各种应用，如纳米输送系统、纳米肌肉和纳米机器人的致动器。拟议项目的主要目标是：在分子水平上确定控制蛋白质吸附模式的碳纳米管的关键物理化学性质，并制定导致有利生物反应的制造方案。通过表面功能化和改进配方方案来优化碳纳米管的生物相容性，验证碳纳米管在医疗应用中的使用。我们计划开发新的基于碳纳米管的生物材料，作为组织再生的支持和低密度脂蛋白伸缩纳米抓握器。

Nanotechnology is likely to evolve rapidly into further complexity where nanorobots that consist of many different nanomaterials will be made. Recently, nanomaterials have received an enormous amount of attention to create new types of tools for life sciences. In our Laboratory, we selected two smart nanomaterials which can be non-invasively driven by an external power source such Magnetic Resonance Imaging. Theses nanomaterials are Carbon NanoTubes (CNTs) and Magnetic NanoParticles (MNP). An exciting property of CNTs is their ability to efficiently convert electrical energy into mechanical energy. Both nanomaterials have many interesting properties that will eventually lead to a variety of applications as nanodelivery system, nanomuscles and actuators for nanorobots. The main objectives of the proposed project are: identify the key physicochemical properties of CNTs at the molecular level that govern protein adsorption patterns and develop a fabrication protocol that leads to a favourable biological response. Validate the use of carbon nanotubes for medical applications via the optimization of their biocompatibility by surface functionalization and improvements in the formulation protocol. We plan to develop new CNT- based biomaterials as a support for tissue regeneration and a low-density lipoprotein telescopic nanograsper.