Regulation of Angiotensin-Converting Enzyme -2 Expression in Liver Injury

肝损伤中血管紧张素转换酶-2表达的调节

• 批准号: nhmrc : 384183
• 负责人: Dr Fiona Warner
• 金额: $ 20.19万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-angiotensin-converting-liver-injury/77798
• 关键词: Regulation; Angiotensin; Converting; Enzyme; Expression

Very recent studies suggest Angiotensin-Converting Enzyme-2 (ACE2) a newly discovered enzyme, normally undetectable in the liver is markedly increased in liver disease in both man and rats. We have recently identified human liver cell lines that endogenously express ACE2 giving us a unique opportunity to investigate the function of this enzyme. The aim of the present project is to provide further insights into the role of ACE2 in liver disease by determining the regulation, location and transport of ACE2 in cultured liver cells as well as in rat models of liver injury.

最近的研究表明，血管紧张素转换酶-2 （ACE2）是一种新发现的酶，通常在肝脏中检测不到，在人类和大鼠的肝脏疾病中都显着增加。我们最近发现了内源性表达ACE2的人肝细胞系，这给了我们一个独特的机会来研究这种酶的功能。本项目的目的是通过确定ACE2在培养肝细胞和肝损伤大鼠模型中的调节、定位和转运，进一步了解ACE2在肝脏疾病中的作用。