THE ROLE OF THE HEPATOCYTE HEDGEHOG PATHWAY IN PROGRESSIVE LIVER INJURY

肝细胞 Hedgehog 通路在进行性肝损伤中的作用

• 批准号: nhmrc : 632701
• 负责人: Dr Fiona Warner
• 金额: $ 38.07万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-hepatocyte-hedgehog-liver-injury/99951
• 关键词: ROLE; HEPATOCYTE; HEDGEHOG; PATHWAY; PROGRESSIVE

This research plan investigates the role of a pathway, known as the Hedgehog pathway, in the development of liver disease which can result in end-stage scarring known as cirrhosis and even lead to liver cancer (known as Hepatocellular carcinoma). Hepatocellular carcinoma is the globally the third most common cause of cancer death and our research will help to better understand how liver injury develops and how this then leads to liver cancer.

这项研究计划调查了一种被称为Hedgehog途径的途径在肝脏疾病发展中的作用，这种疾病可能导致称为肝硬化的终末期疤痕，甚至导致肝癌（称为肝细胞癌）。肝细胞癌是全球第三大最常见的癌症死亡原因，我们的研究将有助于更好地了解肝损伤如何发展以及如何导致肝癌。