Taking elemental analysis from micro- to nano-

如今，随便拿起一本杂志或报纸，几乎都会看到有关纳米科学、纳米技术或“材料科学与技术”对社会影响的报道。除了大众媒体外，以纳米为前缀的新的科学期刊和国际技术会议也在不断推出。此外，美国、欧洲和亚洲的政府、大学和其他研究机构正在大力投资纳米相关领域的研究。在工业方面，美国国家科学基金会和第七届欧洲研究框架等备受尊敬的组织估计，纳米相关领域的未来市场将达到（十年内）“一万亿美元”。所有这些都使nano成为一个明显的机会。不那么明显的是（尤其是在大众媒体中），纳米也代表着一个重大的研究挑战。例如，随着可用于分析的材料（或样品）的总量逐渐变小（例如，从微到纳米），以及必须在如此微量的样品中测定的杂质浓度不断降低（例如，由于推进纳米科学和技术所需的更高纯度材料的要求），在逐渐减少的样品中测量较低浓度的杂质的能力成为一个令人生畏的分析挑战。拟议工作的目标是发现可以应用于开发方法和仪器的新知识，以帮助应对这一挑战；并发明小型化仪器，以降低分析成本，从而使微观，特别是纳米元素分析更广泛地应用。拟议的工作将为发现和产生知识创造特殊的机会；促进创新、发明和创造财富；更重要的是，培养了高素质的人才。参与拟议研究的人员所获得的高科技技能和知识将使他们在与全球任何主要学术、政府和工业实验室的同行竞争中处于领先地位。

One can hardly pick up a magazine or newspaper these days without reading a story about nano-science, nano-technology or on the impact of "materials science and technology" on society.  In addition to the popular press, new scientific journals and international technical conferences with nano- as a prefix are being launched constantly.  Furthermore governments, universities and other research institutions in the US, Europe and Asia are investing heavily on research in nano-related areas.  As for industry, highly respected organizations such as the National Science Foundation in the US and the 7th European Research Framework estimate that future markets in nano-related areas will reach (within a decade) "a trillion dollars".  All of these make nano an obvious opportunity.  What is not made so obvious (especially in the popular press) is that nano also represents a major research challenge.  For example, as the total amount of material (or sample) available for analysis becomes progressively smaller (e.g., from micro- to nano-) and as the concentrations of impurities that must be determined in such tiny amounts of sample are continuously lowered (e.g., due to requirements for higher purity materials needed to advance nano-science and -technology), the ability to measure lower concentrations of impurities in progressively smaller amounts of sample becomes a daunting analytical challenge.       The goals of proposed work are to discover new knowledge that can be applied to development of methods and instrumentation that will help meet this challenge; and to invent miniaturized instrumentation that will reduce the cost of analysis, thus making micro and especially nano elemental analysis more widely available.      Proposed work will create exceptional opportunities for discovery and knowledge-generation; for innovation, invention and wealth generation; and importantly, for training of highly qualified personnel.  The high-tech skills and knowledge obtained by those involved in proposed research will put them in a leading position to compete with their peers from any major academic, government and industrial lab worldwide.