Regulation of autoimmunity by non-apoptotic caspases

非凋亡半胱天冬酶调节自身免疫

• 批准号: nhmrc : GNT1124288
• 负责人: Dr Joanne O'Donnell
• 金额: $ 31.88万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-autoimmunity-non-apoptotic-caspases/1347395
• 关键词: Regulation; autoimmunity; non; apoptotic; caspases

Excessive cell death can lead to chronic inflammation and autoimmunity. Cells can die by different mechanisms including necroptosis which causes inflammation, and apoptosis which does not. Recent studies show that caspases, a component of the apoptosis pathway which accelerate cell death, also prevent immune activation by dying cells. I will investigate whether caspases contribute to autoimmune disease and whether caspases can dampen the inflammation that occurs during necroptotic cell death.

过度的细胞死亡可导致慢性炎症和自身免疫。细胞可以通过不同的机制死亡，包括引起炎症的坏死下垂和不会引起炎症的细胞凋亡。最近的研究表明，半胱天冬酶是细胞凋亡途径中加速细胞死亡的一个组成部分，也可以阻止垂死细胞的免疫激活。我将研究半胱天冬酶是否与自身免疫性疾病有关，以及半胱天冬酶是否能抑制坏死细胞死亡期间发生的炎症。