Regulation of extrinsic death pathways in neutrophils

在感染期间，尽管炎症组织中有大量的中性粒细胞死亡信号，但中性粒细胞的寿命通常会延长。据报道，在与流感、链球菌、呼吸道合胞病毒和巨细胞病毒感染相关的疾病中，中性粒细胞的寿命发生了变化。我们的研究发现了中性粒细胞两条主要的死亡途径之间的关系，表明其中一条死亡途径的改变保护中性粒细胞免受来自第二条死亡途径的死亡信号的影响。

During infection, the lifespan of neutrophils normally increases despite an abundance of neutrophil death signals in inflamed tissues. Altered lifespan of neutrophils has been reported in diseases associated with influenza, Streptococcus, RSV and cytomegalovirus infection. Our research has discovered a relationship between the two dominant death pathways in neutrophils, indicating that alterations in one death pathway protect the neutrophil from death signals from the second death pathway.