Regulation of extrinsic death pathways in neutrophils

中性粒细胞外源性死亡途径的调节

• 批准号: nhmrc : 1017387
• 负责人: Dr Joanne O'Donnell
• 金额: $ 5.64万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-extrinsic-death-pathways-neutrophils/109857
• 关键词: Regulation; extrinsic; death; pathways; neutrophils

During infection, the lifespan of neutrophils normally increases despite an abundance of neutrophil death signals in inflamed tissues. Altered lifespan of neutrophils has been reported in diseases associated with influenza, Streptococcus, RSV and cytomegalovirus infection. Our research has discovered a relationship between the two dominant death pathways in neutrophils, indicating that alterations in one death pathway protect the neutrophil from death signals from the second death pathway.

在感染期间，尽管发炎组织中存在大量的中性粒细胞死亡信号，但中性粒细胞的寿命通常会增加。在与流感、链球菌、RSV和巨细胞病毒感染相关的疾病中，已报告了中性粒细胞寿命的改变。我们的研究发现了中性粒细胞中两种主要死亡途径之间的关系，表明一种死亡途径的改变可以保护中性粒细胞免受第二种死亡途径的死亡信号的影响。