Regulation of body composition and glucose homeostasis by the adaptor protein Grb10.

通过接头蛋白 Grb10 调节身体成分和葡萄糖稳态。

• 批准号: nhmrc : 481335
• 负责人: Andrew Ward
• 金额: $ 41.16万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-body-composition-protein-grb10/81652
• 关键词: Regulation; body; composition; glucose; homeostasis

Resistance to the hormone insulin underlies the development of Type 2 Diabetes. Loss of muscle mass in the elderly contributes to insulin resistance. Recently we identified Grb10 as a new regulator of insulin action and muscle mass. In this proposal, we aim to study how Grb10 affects development and growth of muscle and fat, and the underlying molecular mechanisms. This may lead to new strategies for improving body composition and treating the insulin resistance associated with Type 2 Diabetes.

对激素胰岛素的抵抗是2型糖尿病发生的基础。老年人肌肉质量的丧失会导致胰岛素抵抗。最近，我们发现Grb10是一种新的胰岛素作用和肌肉质量调节因子。在这项提案中，我们旨在研究Grb10如何影响肌肉和脂肪的发育和生长，以及潜在的分子机制。这可能导致改善身体成分和治疗与2型糖尿病相关的胰岛素抵抗的新策略。