Regulation of Endothelin Converting Enzyme Subcellular Distribution and Vascular Endothelin Production.

内皮素转换酶亚细胞分布和血管内皮素产生的调节。

• 批准号: nhmrc : 268913
• 负责人: Prof Alexander Smith
• 金额: $ 26.66万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-endothelin-converting-endothelin-production/83054
• 关键词: Regulation; Endothelin; Converting; Enzyme; Subcellular

Endothelin is a hormone produced by the endothelial cells that line blood vessels. The role of this hormone is cause blood vessels to constrict (vasoconstriction), thus causing a rise in blood pressure. The synthesis of this hormone is crucially dependant on an enzyme that has to be located on the surface of the endothelial cell. The aim of this grant is to understqand the mechanisdms by which the location of this enzyme within the cell is regulated. The knowledge gained from this study will not only help us better understand the mechanism of endothelin production but it may also offer an insight into future therapeutic startegies to prevent the formation of endothelin, thus preventing vasoconstriction.

内皮素是一种由血管内皮细胞产生的荷尔蒙。这种荷尔蒙的作用是使血管收缩，从而导致血压升高。这种激素的合成在很大程度上依赖于一种必须位于内皮细胞表面的酶。这项资助的目的是为了了解这种酶在细胞内的位置被调节的机制。从这项研究中获得的知识不仅有助于我们更好地了解内皮素的产生机制，而且也可能为未来的治疗方案提供洞察力，以防止内皮素的形成，从而防止血管收缩。