Melanocortin Regulation of Reproduction

黑皮质素对生殖的调节

• 批准号: nhmrc : 545918
• 负责人: Prof Alexander Smith
• 金额: $ 39.47万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/melanocortin-regulation-reproduction/78292
• 关键词: Melanocortin; Regulation; Reproduction

Reproduction is controlled by the brain through the hormone gonadotropin releasing hormone (GnRH). Leptin from fat acts on the brain to 'inform' GnRH cells of metabolic state; low levels signal lack of energy stores and suppress reproduction. Leptin treatment of lean individuals restores reproductive function, but the mechanism is not clear. Our data implicate the melanocortins as a means of transmitting information on metabolic state to GnRH cells and the project investigates this pathway.

生殖由大脑通过促性腺激素释放激素（GnRH）控制。来自脂肪的瘦素作用于大脑，“告知”GnRH细胞代谢状态;低水平信号缺乏能量储存并抑制生殖。瘦素治疗可恢复瘦个体的生殖功能，但其机制尚不清楚。我们的数据表明黑皮质素是将代谢状态信息传递给GnRH细胞的一种手段，本项目研究了这一途径。