ACE2, a New Regulator of the Renin Angiotensin System

ACE2，肾素血管紧张素系统的新型调节剂

• 批准号: nhmrc : 268914
• 负责人: Prof Alexander Smith
• 金额: $ 32.85万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/ace2-new-regulator-renin-angiotensin/76469
• 关键词: ACE2; New; Regulator; Renin; Angiotensin

Angiotensin converting enzyme (ACE) is a key enzyme in the renin-angiotensin system (RAS), converting Angiotensin I to the potent vasoconstrictor Angiotensin II (Ang II). ACE inhibitors have been highly successful in the management of hypertension, are standard therapy following myocardial infarction to delay the development of heart failure, and also reduce the rate of progression of renal disease. Recently, a novel enzyme called ACE2 has been discovered in the heart and kidneys. Unlike ACE, ACE2 causes the formation of the vasodilator, Ang 1-7. We have data in the heart and the kidney that supports the concept that ACE2 acts in a counter-regulatory manner to ACE. We suggest that ACE2 may play an important role to modulate the balance between vasoconstrictors and vasodilators in the heart and kidney. The studies detailed in this proposal are designed to specifically examine the role and regulation of ACE2 in the healthy heart and kidney as well as in cardiovascular and renal disease. The project brings together two groups with complementary skills and techniques, both of whom have collaborations with the discoverers of ACE2, and who have been exploring the role of ACE2 as evidenced from our recent publication (Tikellis et al, Hypertension in press, 2003).

血管紧张素转化酶（ACE）是血管紧张素-血管紧张素系统（RAS）中的关键酶，将血管紧张素I转化为强效血管收缩剂血管紧张素II（Ang II）。ACE抑制剂在高血压的管理中非常成功，是心肌梗死后延迟心力衰竭发展的标准治疗，也降低了肾脏疾病的进展速度。最近，在心脏和肾脏中发现了一种名为ACE 2的新酶。与ACE不同，ACE 2导致血管扩张剂Ang 1-7的形成。我们在心脏和肾脏中的数据支持ACE 2以反调节方式对ACE起作用的概念。提示ACE 2可能在调节心脏和肾脏血管收缩和舒张的平衡中起重要作用。本提案中详述的研究旨在专门研究ACE 2在健康心脏和肾脏以及心血管和肾脏疾病中的作用和调节。该项目汇集了两个具有互补技能和技术的小组，这两个小组都与ACE 2的发现者合作，并且他们一直在探索ACE 2的作用，正如我们最近的出版物所证明的那样（Tikellis等人，Hypertension in press，2003）。